NSI 189 Review (Suprising ‘Side Effect’)

NSI-189 Review – Updated 2019


NSI-189 is a nootropic drug & potential anti-depressant that is still in the clinical-experimental stages of research.

It has been shown in studies to alleviate major depressive symptoms and to increase the size of the hippocampus (the ’emotional’ part of the brain) by generating new brain cells.

Depression & loss of brain cells are both related issues in the world of MMA.

Check out Cat Zigano for example, discussing the issues on the Joe Rogan Podcast.




There is some good information about NSI 189 on the self-hacked website and also on reddit.com:




NSI 189 for Depression

I’ve had depression & anxiety literally since I can remember. It hit it’s peak post-university-graduation. It was a bit of a vicious cycle, I’d feel depressed, lethargic and extremely ‘foggy’ and then (understandably to a certain extent) people treated me like I was thick as sh!t (despite having a first class degree & an MSc) and then I’d feel sorry for myself, more depressed and worse…I was suicidal on and off for a few years.

Anyway, pity party over, I’ve gone to extreme lengths to take ownership of this problem – I hate it when people blame a black dog or external factors – for me diet, exercise, meditation, getting outdoors more and doing yoga have all had a massive, positive impact on me. Stoic philosophy is also great by the way.

I improved greatly over the years and reached a stage where I was a bit kinda bored and pissed off a lot of the time; rather than clinically depressed.

I’ve had 4 concussions, one put me in the hospital for a few days, so I thought brain injury might also be something that’s causing my lethargy.

So; probably stupidly, after trying lions mane mushroom which also increases brain cells, I thought I’d try NSI 189.

I took 40mg for 6 weeks and my energy levels are definitely up. It doesn’t help with anxiety but I definitely don’t feel like I have to drag myself places, or to work anymore, I’ve got more of a spring in my step.

It’s not something I can recommend, because for all I know my brain might actually be in worse shape a few years down the line – I don’t think there are any long term studies – but if you are very depressed, this, or even psychedelic mushrooms (in a safe & controlled setting with guidance) are potential ‘solutions’.


NSI 189 Review

For me, after taking for 6 weeks – 1 month later, I can say I’ve had some good results. More energy and much more vivid eyesight too. Especially when outdoors – outlines and distances seem much clearer – it’s pretty cool.

Oh the surprising side effect – this was the improvement in my depth perception and long distance eyesight!

Good luck and please leave a comment with any questions

Bonus tip:

It seems to go great with a microdose 🙂



Article for Entertainment Only. Consult your doctor etc.



About Drew

MMA, Fitness & Marketing enthusiast from North Wales, UK. A Stoic Hippy with no hair. Not to boast but - 1st Class Degree in Sports Science from Loughborough, MSc in Nutrition from the University of Liverpool. 20 years experience of weight & fitness training.
This entry was posted in MMA, Nutrition, Philosophy, Psychology and tagged , , , , . Bookmark the permalink.

2 Responses to NSI 189 Review (Suprising ‘Side Effect’)

  1. Rich says:

    I have suffered the same and through doctors misdiagnosing for years they now say i am adukt ADHD and MDD. I have to agree. I also had bad concussions when younger and read about Temporal Lobe ADD……. nail on the head. Ive tried so many nootropic and otherwise mixed concotions (or stacks as some like to call). Not tried NSI-189 but may. Also Bromantane is really good for all of the functions you appear to need it for.

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