CBD Oil – An Overview

CBD Oil is not psychoactive – i.e. you can not get high from taking or using it. It contains very little THC.

CBD oil is very effective for headaches, migraines, anxiety and any health complications that are related to inflammation. For medicinal purposes it is normally used in the dropper/liquid form, rather than the vaping form. You can buy it from CBD Brothers, it’s expensive, but their customer service is very good. There are also a range of products available on Amazon and Ebay.

cbdoil

Below is scientific evidence & research that relates to either directly or indirectly the influence of CBD and cannabinoids on different health problems and diseases.

Note that a lot of the research concludes that cannabis or cannabinoids have potential use in the treatment of a specific condition. There’s such mounting scientific and anecdotal evidence however, that there seems very little doubt surrounding the benefits…

This study examines the possibility that a deficiency in the body’s own naturally produced cannabinoids, causes a range of health problems.

Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?

OBJECTIVES:

This study examines the concept of clinical endocannabinoid deficiency (CECD), and the prospect that it could underlie the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis.

CONCLUSION:

Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines.


 

This case review examines the way in which cbd oil can ease the suffering related to inflammatory bowel disease

Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview

In the past, Cannabis preparations have been considered new promising pharmacological tools in view of their anti-inflammatory role in IBD as well as other gut disturbances. However, their use in the clinical therapy has been strongly limited by their psychotropic effects. CBD is a very promising compound since it shares the typical cannabinoid beneficial effects on gut lacking any psychotropic effects. For years, its activity has been enigmatic for gastroenterologists and pharmacologists, but now it is evident that this compound may interact at extra-cannabinoid system receptor sites, such as peroxisome proliferator-activated receptor-gamma. This strategic interaction makes CBD as a potential candidate for the development of a new class of anti-IBD drugs.


 

Another study looking at cbd and gut health – remember that gut inflammation and permeability has been linked to systemic inflammation and depression.

Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability

CONCLUSIONS AND IMPLICATIONS These findings suggest that locally produced endocannabinoids, acting via CB1 receptors play a role in mediating changes in permeability with inflammation, and that phytocannabinoids have therapeutic potential for reversing the disordered intestinal permeability associated with inflammation.


 

Another study on gut inflammation

Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis

BD targets enteric reactive gliosis, counteracts the inflammatory environment induced by LPS in mice and in human colonic cultures derived from UC patients. These actions lead to a reduction of intestinal damage mediated by PPARgamma receptor pathway. Our results therefore indicate that CBD indeed unravels a new therapeutic strategy to treat inflammatory bowel diseases.


 

A study relating to CBD and Parkinson’s disease

Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease.

…In summary, our results support the view of a potential neuroprotective action of cannabinoids against the in vivo and in vitro toxicity of 6-hydroxydopamine*, which might be relevant for PD (Parkinson’s Disease). Our data indicated that these neuroprotective effects might be due, among others, to the antioxidant properties of certain plant-derived cannabinoids, or exerted through the capability of cannabinoid agonists to modulate glial function, or produced by a combination of both mechanisms.

 *Oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. Wikipedia
It is used to model Parkinson’s disease in animal studies.

CBD for migraines:

Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population.

CONCLUSION:

The frequency of migraine headache was decreased with medical marijuana use. Prospective studies should be conducted to explore a cause-and-effect relationship and the use of different strains, formulations, and doses of marijuana to better understand the effects of medical marijuana on migraine headache treatment and prophylaxis.

https://www.ncbi.nlm.nih.gov/pubmed/26749285


Anecdotal Evidence Supporting Medicinal Use of CBD Oil

At 39:40 Shannon Briggs talks how CBD Oil helped with his mental health problems


 

At 26:30 Former Glory World Champion Kickboxer Joseph Valtellini talks about how CBD Oil was the only think which helped him recover from a fight-induced concussion


 

The now famous “ride with Larry video”. Showing the effects of cbd on Parkinson’s – Although I’m not 100% sure if he uses pure cbd oil or a a full cannabis spectrum.

 

Is CBD Oil Legal in the UK?

From what I’ve read, it is legal as long as the retailer has a license. More info here and here.

It has recently become classed as a medicine as well, which appears to be a positive move towards general acknowledgement of the health benefits associated with CBD.

If you want further information on CBD Oil, Reddit is normally a good place to search and look around –

Studies regarding CBD Oil can be found on Google Scholar

 

Final Note

CBD Oil is very effective for a range of ailments and has a robust amount of research supporting this.

If you are suffering from muscle tension or anxiety, I would first recommend trying magnesium glycinate as it is so much cheaper than CBD. If this doesn’t help, then try CBD.

For inflammation, your first port of call should be to increase omega 3 and decrease omega 6 from sunflower oil etc. Look to get a fish oil high in EPA. Robb Recommends 2g to 4g of combined EPA & DHA per day – look at the back of the packet to see how much EPA & DHA you get in each serving of your fish oil.

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